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KMID : 1140120050100040257
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Cancer Prevention Research
2005 Volume.10 No. 4 p.257 ~ p.263
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Inhibitory Effect of Angelica keiskei Koidz on the Mutagenicity Induced by Various Mutagens and the Growth of Human Cancer Cells
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Moon Suk-Hee
Ha Jung-Ok
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Abstract
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The inhibitory effects of various vegetable juices on the mutagenicities in Ames test, spore rec assay and the growth of AZ-521 human gastric cancer cells and MG-63 human osteocarcinoma cells were studied. Antimutagenic activities toward aflatoxinB1 (AFB1) and N-methyl-N’-nitro-N-nitrosoguanidine (MNNG) were observed when juices of Angelica keiskei Koidz, sowthistle, beet, comfrey and native lettuce were added in the Salmonella typhimurium TA100. Especially the juice of Angelica keiskei Koidz showed strong antimutagenic activity on AFB1. In spore rec assay using B. subtilis H17 (Rec ) and M45 (Rec ), the juice of Angelica keiskei Koidz also showed the same effect. The juice of Angelica keiskei Koidz also revealed the inhibitory effects on the growth of AZ-521 human gastric cancer cells and MG-63 human osteocarcinoma cells.
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KEYWORD
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Angelica keiskei Koidz, Antimutagenic activity, AZ-521 human gastric cancer cells, MG-63 human osteocarcinoma cells
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